Watch what changes your income
After an upgrader or new system unlock, give it time to affect the money flow. This makes it easier to see which purchases actually help your current run.
Keep currencies separate
Money, Bits, Essence, Prestige Points, seeds, and wheat have different uses. Avoid treating them as interchangeable; check the shop or system that asks for each one before spending.
Reset with a purpose
Rebirth is a progression tool. Before using it, make sure you understand the permanent benefit you expect to receive and what you will rebuild first.